3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase
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Comparison Between HPLC and HPTLC Densitometry for the Determination of 11-keto-β-boswellic acid and 3- acetyl-11-keto-β-boswellic acid from Boswellia serrata Extract
Objective: Boswellic acids (BAs) are active constituents of plant Boswellia serrata. In the present study boswellic acids were extracted from Boswellia serrata and dry methanolic extracts were quantified by HPLC and HPTLC. Method: A gradient HPLC method was used for the quantification of the boswellic acids; 11-keto-β-boswellic acid (KBA) and 3acetyl-11-keto-β-boswellic acid (AKBA). A direct HP...
متن کاملNeuroprotection by Acetyl-11-Keto-β-Boswellic Acid, in Ischemic Brain Injury Involves the Nrf2/HO-1 defense Pathway
Stroke is a complex disease involved oxidative stress-related pathways in its pathogenesis. The nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway has been considered a potential target for neuroprotection in stroke. Acetyl-11-Keto-β-Boswellic Acid (AKBA) is an active triterpenoid compound from the extract of Boswellia serrate. The present study was to determine ...
متن کاملPharmacokinetic study of 11-Keto -Boswellic Acid
Introduction: Boswellia serrata has been used in traditional medicine for treatment of inflammatory diseases since antiquity. However human kinetic studies are lacking for this. Hence to better elucidate its effects in humans and determine its optimal dosing, this study was planned. Material and Methods: Twelve healthy adult men volunteers were given capsule Wok Vel containing 333 mg of Boswel...
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Molecular docking is a bioinformatics tool used to study and analyse ligand receptor interactions. This helps in identifying the receptors (molecular targets) for different ligands. Using these technologies, compound isolation and drug discovery from herbals is achieved. Herbs are widely used in treatment of various ailments from time immemorial. Phytochemists and drug developers are now intere...
متن کاملAnalgesic activity of acetyl-11-keto-beta-boswellic acid, a 5-lipoxygenase-enzyme inhibitor
Acetyl-11-keto-beta-boswellic acid (AKBA) is one of the four major pentacyclic triterpenic acids present in the acidic extract of the Boswellia serrata gum resin that is used for a variety of inflammatory disorders, such as rheumatoid arthritis, osteoarthritis, and cervical spondylosis. AKBA is a novel, highly specific inhibitor of 5-lipoxygenase, the key enzyme for leukotriene biosynthesis. It...
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ژورنال
عنوان ژورنال: Journal of Experimental & Clinical Cancer Research
سال: 2018
ISSN: 1756-9966
DOI: 10.1186/s13046-018-0805-4